Creating Order from Chaos: Cellular Regulation by Kinase Anchoring

Creating order from chaos: cellular regulation by kinase anchoring.

Second messenger responses rely on where and when the enzymes that propagate these signals become active. Spatial and temporal organization of certain signaling enzymes is controlled in part by A-kinase anchoring proteins (AKAPs). This family of regulatory proteins was originally classified on the basis of their ability to compartmentalize the cyclic adenosine monophosphate (cAMP)-dependent pro...

Creating Order From Chaos

Pathogenesis of nearly all arrhythmia relies on a fundamental premise—that there exists within the cellular milieu regions of unexpected or unwanted heterogeneous conduction that may allow for initiation and propagation of wave fronts along a nonstandard pattern. The simplest paradigm for this may be atrioventricular reentrant tachycardias wherein 2 paths exist, both capable of propagating sign...

Order from Chaos

One of the greatest achievements of 20th-century mathematics is the exploitation of random or stochastic models to bring intellectual order out of apparently chaotic natural processes. From statistical mechanics to human behavior, the hypothesis of randomness has made possible greater accuracy in predicting the course of events than did even the full elaboration of Newtonian mechanics. This shi...

Psychological distress and medication adherence: creating order out of chaos?

Creating order out of chaos: a leadership approach.

Communication is of the utmost importance for effective teamwork, yet promoting effective communication and overcoming the cultural belief that conflict is "bad" are key challenges for leaders. To provide optimal patient care, perioperative nurse leaders should assess the culture in which they work and develop strategies to build solid credible relationships within their teams. This article int...